DNA(一) 序章
写这个系列的目的是为了回答一个问题:基因、氨基酸和蛋白质三者之间的关系。在分子生物学里描述这三者间传递规律的内容称为中心法则(Central dogma of molecular biology),可见其重要意义。其中氨基酸和蛋白质的关系非常简单,一个个氨基酸相连就成了蛋白质。但从基因到氨基酸的过程却比较复杂,要转两个弯,涉及到转录和翻译两个过程,而这两个过程相当奇妙,其奇异程度曾使我一度感觉生命好像源于设计。这一系列谜底的揭开都得益于DNA的发现,所以回答这个问题不得不从介绍DNA开始
这些都是分子生物学的基本知识,里面涉及许多抽象的概念,比如刚刚提到的转录、翻译,还有复制、逆转录、启动子、终止子、密码子,回文结构,等等等等,这些抽象概念涉及的过程时时刻刻发生在我们的体内,它们管理着我们,而我们却毫无察觉。可一旦这些过程出了问题,疾病就会随之而来,有些可能致命
我不是分子生物学家,我也不清楚我表达能力能否把这些过程讲清楚,但会尽量尝试用平常的语言讲述这些道理。无论如何,如果你觉得太枯燥,看不下去,或者不懂,那不是你的错,都怪我写的不生动或者没说清楚
欢迎提问,什么问题都可以,我尽量回答,如果答不出来,我会求教身边的同学,再给出解释
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DNA(一) 序章
人类必定无法看到宇宙毁灭的一幕,而且可以肯定的是,在太阳系毁灭之前,人类早已不存在了。以宇宙的时间标准,人类文明的长度可以忽略不计。自以为是的人类在宇宙的力量面前不值一提
一种理论认为现在的宇宙会无限制的膨胀下去,最终是一个极其寒冷、死寂的状态,所有的恒星都死去,没有了光和热
当然还有一种理论,宇宙膨胀到一个临界点后,开始回缩,时光倒流,死去的我们又将复活,重新相聚,然后越过越年轻,当然最终还是要面对永远的分离
好像后一种理论还可以接受,毕竟它能给我们再活一次的机会,那些逝去的人还能再见上一面。但我隐约感觉这不可能
终有一天,我们的后代会面对一个恐怖的结束,恶劣的环境将使生物无法生存,而且这个悲剧结果并不是由人类造成的(人类别太自恋,你的能力并不能使所有生物灭绝),来自宇宙的无法抗拒的物理学力量也许会破坏太阳系那脆弱的平衡,也许只要行星的运行轨道在外力的作用下稍作改变,生物可能就会从地球上消失。所以,幸好,我们活在现在
毁灭必定发生,我们不去管它,因为它太遥远。但至少在离开这个世界之前,我们应该去关心一下生命如何起源,它是个让人非常着迷的话题,它曾经确确实实的发生过
人类通过伟大的哈伯望远镜可以一窥宇宙的初始时刻,而另一个极端,人类尝试在分子层面揭示生命的本质。相比那些曾经探索过这些秘密却没有收获的先驱们,我们已经很幸运了,至少我们得知宇宙可能产生于大爆炸,而且我们还发现了DNA,它们都可以比较完美的解释许多现象
首先感谢那几个科学家,让我们知道了DNA,其实我们最该感谢的是促成这个伟大发现的研究体系。另外,不得不自卑一下,就是再给1万年,那个建立在阴阳五行理论上的传统医学也不会找到细胞核,更别提里面的DNA了
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下一篇:《DNA(二) 前传 》将于明日贴出
Yanhu老师开课喽!!我来码板凳,安静安静,好好听讲了~~
沙发我不抢,空着呢,留给S因素留给S因素
举手发言:
“后一种理论”,确实对心灵是个安慰:十个海子,全部复活。
如是复活,该不只是人类,而是全部有灵的生物,是否也包括微生物与草履虫?如此几十亿间的生灵一起欢歌,怕只能是一瞬吧,地球爷爷承载不住。。。
“抽象概念”和“五行”:在这些抽象概念存在之前,它意指的标的物和运行规律已经存在了千万年了,我们还只是卑微的探索着描述着学习着。“无极生太极,太极生两仪”,这些哲学含在中医和传统养生里,不就是你洋洋洒洒的这一大篇么。
西医是技术,中医是养生哲学,不用比较高低的。
如果硬要比,Nana说科学是1.0版,哲学是2.0,宗教是3.0,文学是4.0
嘿嘿
“DNA(二)前传”:颇有点儿星球大战的意思……
嗯,能提前剧透一下,最后一篇叫什么么,,,比如,,,DNA(九)启示录?
我也搬来凳子坐下了,先扫扫盲,不然都没法提问。
@欣燃
欣燃同学,祝今天快乐 ~
时间倒流是难以想象的,它不是所有生物的一起复活,而且曾今发生的事倒着来一遍,慢慢回到曾今爆炸的那个点,这个过程是不符常识的
传统医学还在给人看病,尽管它不断的采用西医的辅助检查方法和西药,给自己以中西医结合的包装,但是它还是不能符合科学的定义。关于什么是科学,这儿有篇短文,写得很好,就是得用心读:http://www.bullock.cn/blogs/songshuhui/archives/151156.aspx
DNA(二)只是个热身,关于中心法则,会在DNA(三)和(四)中提及。最后一篇还没写好,能把《中心法则》讲清楚的话,我就心满意足了,在此基础上,我也许会谈谈基因诊断、基因治疗、转基因食物等等
启示录,倒是个非常不错的名字,曾经挺喜欢的一部马龙.白兰度的电影就叫《现代启示录》,用这个名字,得站在一定的高度,好像我还达不到,不敢用
再次祝好
@小象
有的时候我是发自内心的希望别人了解这些知识,它是那么的奇妙,甚至能改变一个人的人生观
那一刻,也许会叹口气,哦,原来是这样
好好学习!
@起子
那就让我们天天向上吧
……
挠了挠脑袋,有点儿汗,谢谢你祝我今天快乐
嘿嘿~~
再谢一次吧,嗯
对于爆炸的逆行,我猜测那会是速度非常快的急剧收缩。不知道是直觉猜测,还是扫过一集的《霍金的宇宙》里听来的,记不清了。如果是,对于生命还是不得期待的。
我没说中医是科学。。我不懂不敢乱说,它更像是感性认识的抽象梳理吧。。
至于定义,一位学国政的朋友曾给我简单解释过概念和概念群,她说讨论要先建立在对基本概念的基本认同上。
你转的帖子,对科学的定义,第一句我就不认同。
仔细再看,中英文不是一个意思的。还是我没读懂。。
《现代启示录》,大家都盯着马龙。。我不,我喜欢Martin Sheen,超喜欢。我不喜欢奶油小生,他在这部片子里小生,但不奶油。演技也超好。
据说,《启示录》是《新约》的最后一卷,我没有读过。俺是想,你会不会写DNA启示录,呵呵。
@欣燃
我对那句的理解是:科学是一种方法,知识只是它的产品,科学只是求知的过程。随着科学方法的完善,知识不断的被更新,很难说什么是真理,因为人类的理解总是有局限性的,比如牛顿建立在当时看似完美的经典力学体系又被爱因斯坦否定,但我们不会贬低牛顿,只会惊叹爱因斯坦的智慧,这也许就是科学的魅力
那个个子不高的男人原来叫Martin Sheen,印象很深,也很喜欢
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